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氟喹诺酮类药物是目前国际上倍受重视的合成抗菌药。自60年代发现并合成以来,已发展到第三代,其抗菌作用优于第三代头孢菌素。目前已投入临床使用的氟喹诺酮类药物是:氟哌酸(诺氟沙星norifloxacin)1977年日本杏林公司开发,1978年日本、美国合制;甲氟哌酸(培氟沙星pefloxacin)1979年法国、日本合成;氟啶酸(依诺沙星enoxacin)1980年日本合成,1986年1月出售;1989年中国合成;氟嗪酸(氧氟沙星ofloxacin)1981年日本合成;环丙氟哌酸(环丙沙星ciprofloxacin)1983年德国合
Fluoroquinolones are the most important synthetic antibacterials in the world at present. Since its discovery and synthesis in the 1960s, it has developed into the third generation with better antibacterial activity than the third generation cephalosporins. Fluoroquinolones currently in clinical use are: Norfloxacin Norifloxacin Developed by Japan’s Kyorin Corporation in 1977, Japan, United States, 1978; mefloxacin (pefloxacin), 1979 France and Japan; synthesis of enoxacin by Japan in 1980, synthesis by Japan in January 1986; synthesis by China in 1989; synthesis of ofloxacin byloxacin in Japan in 1981; synthesis of ciprofloxacin Acid (ciprofloxacin 1983 Germany together