论文部分内容阅读
SMZCo系磺胺甲基异噁唑和甲氧苄胺嘧啶按规定配量组合而成,能对细菌叶酸代谢起双重阻断作用。由于该药广泛用于临床,体内过程较为特殊。如血浆蛋白结合率高,需经肝脏乙酰化,有一定的药酶抑制作用,酸性尿中溶解度低等,故在与其他药物合用时会产生复杂的相互作用。由于上述情况,我们对281张处方作如下分析。 材料与方法 收集1997年6月26日至7月10日,15天各科门诊处方共计7097张,其中含SMZCo的处方423张,而不合理合用者281张,根据SMZCo与其他药物的相互作用进行归类处理。
SMZCo Department of sulfamethoxazole and trimethoprim in accordance with the provisions of the combination of dosage, can play a double blocking effect on bacterial folic acid metabolism. As the drug is widely used in clinical, the body process is more special. Such as high plasma protein binding rate, to be acetylated by the liver, a certain drug enzyme inhibition, low solubility in acidic urine, so when combined with other drugs will have a complex interaction. Because of the above, we analyzed 281 prescriptions as follows. MATERIALS AND METHODS Collection From June 26, 1997 to July 10, 1997, a total of 7097 outpatient prescriptions were given to 15 outpatients, including 423 SMZCo prescriptions and 281 unreasonable users. According to the SMZCo interaction with other drugs For classification.