大量研究显示丙型肝炎病毒(hepatitis C virus, HCV)持续感染肝细胞能导致肝细胞癌(hepatocellu- lar carcinoma,HCC),但其致癌机制目前还不十分清楚。HCV是一种RNA病毒,其基因组不能整合到宿主染色体中引起基因突变,可能是通过其表达的蛋白质引起细胞转化。由于HCV NS3含有多种蛋白酶活性,因而推测HCV NS3在肝细胞癌的形成过程中具有重要作用,本文就HCV NS3致癌机制的研究进展作一综述。 A large number of studies have shown that persistent infection of hepatocytes by hepatitis C virus (HCV) can lead to hepatocellular carcinoma (HCC), but its mechanism of carcinogenesis is still not fully understood. HCV is an RNA virus whose genome cannot be integrated into the host chromosome to cause a gene mutation, probably through the protein it expresses to cause cell transformation. Since HCV NS3 contains multiple protease activities, it is speculated that HCV NS3 plays an important role in the formation of hepatocellular carcinoma. This article reviews the research progress of HCV NS3 carcinogenesis.