目的分析脓毒症患者外周血血小板-白细胞聚集体(PLA)的检验情况。方法选取2013年3月至2015年4月106例脓毒症患者,按照病情程度分成感染性休克组(32例),严重脓毒症组(42例),脓毒症组(32例),并选取同时期健康者30例作为对照组,观察对比各组外周血血小板-中性粒细胞聚集体(PNA)、血小板-单核细胞聚集体(PMA)水平,将28d作为终点对比预后良好组与预后不良组PLA、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)及序贯器官衰竭估计评分(SOFA)。结果感染性休克组PMA、PNA均高于严重脓毒症组、脓毒症组、对照组,且随着病情严重,PMA、PNA水平逐渐上升,差异均有统计学意义(P<0.05)。结论脓毒症患者外周血PLA上升,与脓毒症病变程度存在一定关系,PLA极有可能在脓毒症损伤机制中发挥重要作用。 Objective To analyze the test of peripheral blood platelet-leukocyte aggregates (PLA) in patients with sepsis. Methods One hundred and sixty patients with sepsis from March 2013 to April 2015 were divided into septic shock group (32 cases), severe sepsis group (42 cases), sepsis group (32 cases), septic group Thirty healthy controls were selected as the control group. The levels of PNA and PMA in peripheral blood of each group were compared, and 28 d was taken as the end point to compare the good prognosis group PLA with poor prognosis, acute physiology and chronic health status Ⅱ (APACHE Ⅱ) and sequential organ failure assessment score (SOFA). Results The levels of PMA and PNA in septic shock group were significantly higher than those in severe sepsis group, sepsis group and control group. The levels of PMA and PNA gradually increased with the severity of sepsis (P <0.05). Conclusion The increase of peripheral blood PLA in patients with sepsis is related to the severity of sepsis. PLA is likely to play an important role in the mechanism of sepsis injury.