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以生物活性为导向,应用体外NF-κB报告基因检测法,从旋覆花Inula britannica var.chinensis(Rupr.)Regel地上部分的醋酸乙酯部位分得4个新的倍半萜二聚体inulanolide A~D(1~4)和3个已知单体倍半萜(5~7)。评价了这些化合物对NF-κB活性、NO和TNF-α产生的影响。旋覆花干燥的地上
Using bioinformatics as a guide, four new sesquiterpene dimers inulanolide were obtained from the ethyl acetate site of the aboveground part of Inula britannica var.chinensis (Rupr.) Regel using the in vitro NF-κB reporter gene assay. A~D (1~4) and 3 known sesquiterpenoids (5~7). The effect of these compounds on NF-κB activity, NO and TNF-α production was evaluated. Inula dry on the ground