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巯甲丙脯酸(又名甲巯丙脯酸,SQ14225,caqtopril)是近年来第一个人工合成的口服血管紧张素转化酶的特异性抑制剂,1976年首先由Ondetti等合成,它能阻滞血管紧张素I转变成有血管收缩活性的血管紧张素Ⅱ,从而发挥其降压作用。一、病例选择1.选择无明显心、肾功能损害的原发性高血压患者作为观察对象,排除继发性高血压患者。
Captopril (also known as captopril, SQ14225, caqtopril) is the first synthetic inhibitor of oral angiotensin-converting enzyme in recent years. It was synthesized by Ondetti et al Angiotensin I is converted to vasoconstrictive activity of angiotensin II, which play its antihypertensive effect. First, the case selection 1. Select no obvious heart, renal dysfunction in patients with essential hypertension as the observation object, excluding patients with secondary hypertension.