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目的:观察依达拉奉注射液对高龄急性脑梗死患者颅内动脉血流动力学的影响及评价其临床疗效。方法:选择符合标准的急性脑梗死患者共152例,随机分为治疗组和对照组,观察依达拉奉治疗30 d后的临床疗效及药物对急性脑梗死患者血液流变学的影响。结果:治疗组经依达拉奉治疗后与对照组比较,中国卒中量表(CSS)评分差异有统计学意义(P<0.05);治疗组高龄急性脑梗死患者在疗效和各项血液流变学指标上,都优于对照组;治疗组患者治疗后即刻和治疗后7 d的侧枝循环代偿改善率均优于对照组(P<0.05)。结论:依达拉奉治疗高龄急性脑梗死疗效确切,它能有效改善患者颅内动脉血流动力学,提高神经功能。
Objective: To observe the effect of edaravone injection on intracranial hemodynamics in elderly patients with acute cerebral infarction and evaluate its clinical efficacy. Methods: A total of 152 acute cerebral infarction patients were selected and randomly divided into treatment group and control group. The clinical effects of edaravone 30 days after treatment and the effect of drugs on hemorrheology in patients with acute cerebral infarction were observed. Results: Compared with the control group, the stroke score (CSS) score of the treatment group after treatment with edaravone was significantly different (P <0.05); the treatment group of patients with acute cerebral infarction in the efficacy and various blood rheology (P <0.05). The improvement rate of collateral circulation compensation immediately after treatment and on the 7th day after treatment in the treatment group was better than that in the control group (P <0.05). Conclusion: Edaravone is effective in treating acute cerebral infarction in elderly patients. It can effectively improve hemodynamics and improve neurological function in patients with intracranial arteries.