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利用重复缺氧的方法，研究小鼠间歇性低氧适应和神经节苷脂（Ｇｌｓ）的作用。发现：在小鼠急性缺氧时，血液和脑组织中的谷胱甘肽过氧化物酶（ＧＳＨｐｘ）活性明显下降（Ｐ＜０．０１）；脑组织中的ＧＳＨｐｘ活性在急性重复缺氧时较１次缺氧时升高（Ｐ＜０．０５）；脑组织的Ｇｌｓ含量明显下降（Ｐ＜０．０１）。提示Ｇｌｓ和ＧＳＨｐｘ有相同的抗自由基活性。急性重复性缺氧时Ｇｌｓ下降，去甲肾上腺素（ＮＥ）也下降（Ｐ＜０．０１），不同于持续性低氧的表现。推测脑细胞β受体腺苷酸环化酶系统在急性重复缺氧时未受严重伤害，Ｇｌｓ和缺氧、缺氧保护有关。
The effects of intermittent hypoxic adaptation and gangliosides (Gls) in mice were studied using repeated hypoxia. It was found that GSHpx activity in blood and brain tissue was significantly decreased in acute hypoxia mice (P <0.01). GSHpx activity in brain tissue was significantly increased in acute hypoxia Compared with the first hypoxia (P <0.05), the content of Gls in brain tissue decreased significantly (P <0.01). Suggesting that Gls and GSHpx have the same anti-free radical activity. Acute repetitive hypoxia Gls decreased norepinephrine (NE) also decreased (P <0.01), is different from the performance of persistent hypoxia. Presumably brain cells beta-adenylate cyclase system in acute repeated hypoxia did not suffer serious injury, Gls and hypoxia, hypoxia protection.