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本文作者结合电子显微镜技术和过氧化酶细胞化学技术对1例急性粒细胞白血病的各种病理表现进行了分析。其病理学特征是在白血病的原始和早幼粒细胞中奥氏小体(Auer)形成,成熟的多形核白细胞(PMN)中存在奥氏小体和“裂孔白血病”现象。从治疗前的骨髓和血液观察到患者的异常早幼粒细胞中酶的浓缩和颗粒形成有一定异常:(1)Golgi池中过氧化酶的浓度比正常低;(2)可见大量高过氧化酶活性的小泡,这些小泡可能由粗糙型内质网上绞窄脱落下来,通过Golgi池,聚集而成较大之奥氏小体;或来自Golgi泡,进一步浓缩;(3)
The authors of this paper combined electron microscopy and peroxidase cytochemistry to analyze various pathological features of an acute myeloid leukemia patient. Its pathological features are the formation of auricular bodies (Auer) in the primitive leukemia and promyelocytes, and the presence of auriculoresome and “leaked leukemia” in mature polymorphonuclear leukocytes (PMN). Abnormal enzyme concentration and granule formation in patients with abnormal promyelocytic cells were observed from the bone marrow and blood before treatment. (1) The concentration of peroxidase in the Golgi pool was lower than normal; (2) A large amount of hyperperoxidation was observed. Enzymatically active vesicles, which may be shrunk from the roughened endoplasmic reticulum, aggregated into large austenitic bodies through Golgi pools, or from Golgi bubbles, and further concentrated; (3)