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转移黏附基因(metadherin,metastasis adhesion,MTDH)亦称AEG-1,是2002年发现至今被证实的一个重要的癌基因[1]。研究发现,MTDH在多种恶性肿瘤(如乳腺癌[2]、前列腺癌[3]、胶质瘤[4]、肝癌[5]、食管癌[6]等)中过表达,且与肿瘤发生、发展及临床预后密切相关。MTDH可能主要通过Wnt、PI3-AKT、NF-k B、P38MAPK信号调控、参与正常细胞的恶性转化和肿瘤的进展[7]。因MTDH在多种肿瘤的侵袭和转移中扮演重要角色,我们推测
Metadherin (metastatic adhesion, MTDH), also known as AEG-1, is an important oncogene that has been found in 2002 [1]. It has been found that MTDH is overexpressed in various malignancies such as breast cancer [2], prostate cancer [3], glioma [4], liver cancer [5], esophageal cancer [6] , Development and clinical prognosis are closely related. MTDH may be mainly regulated by Wnt, PI3-AKT, NF-κB and P38MAPK signaling, and is involved in the malignant transformation of normal cells and tumor progression [7]. Because MTDH plays an important role in the invasion and metastasis of a variety of tumors, we speculate