风湿性心脏病是一种常见病、多发病,在发展中国家是危害人们健康的主要的疾病之一。多认为是A型溶血性链球菌感染引起的风湿热的后遗症,是一种自身免疫性疾病。自身免疫性疾病与细胞因子密切相关,细胞因子在风湿热/风湿性心脏病发生发展过程中发挥着重要的作用。对不同的促炎性和抗炎性细胞因子在风湿性心脏病的发生、发展阶段中所起的作用进行综述,有助于进一步认识其分子机制。 Rheumatic heart disease is a common and frequently-occurring disease that is one of the major diseases endangering people’s health in developing countries. Multi-think is hemolytic streptococcus infection caused by the sequelae of rheumatic fever, is an autoimmune disease. Autoimmune diseases are closely related to cytokines, and cytokines play an important role in the development of rheumatic fever / rheumatic heart disease. This review summarizes the roles played by different proinflammatory and anti-inflammatory cytokines in the development and progression of rheumatic heart disease, which helps to further understand its molecular mechanism.