寻找抗病毒物质的系统研究是从五十年代开始,早期工作所依赖的随机筛选方法至今尚未失去其意义。近年来随着对有关病毒结构和生物性质方面日益增多的了解以及一些抗病毒物质作用机理的发现,有目的地设计和合成抗病毒物质已占重要的地位。目前已有很多证据表明,其浓度不足以干扰基本细胞功能而具有显著抑制病毒生长的特异性抗病毒物质是存在的。例如:(1)通 Systematic search for antiviral substances has been around since the 1950s, and random screening methods on which earlier work relies have so far not lost its significance. In recent years, with the increasing understanding of the structure and biological properties of viruses and the discovery of some anti-viral substances, the purpose of designing and synthesizing antiviral drugs has played an important role. There is a lot of evidence that there is a specific antiviral substance that has a concentration that is not sufficient to interfere with basic cellular functions and significantly inhibits the growth of the virus. For example: (1) pass