狗注射内毒素后3～5分钟,血压明显下降,血浆血管紧张素Ⅱ(AⅡ)和儿茶酚胺(CA)均有升高,这可能是由于血压降低而引起的代偿。4小时左右,血压回升,AⅡ和CA亦接近对照水平,动物处于代偿期。临死前血压又再度降低,AⅡ和CA再次升高。AⅡ和CA的变化趋势基本一致,但CA第一次升高的高峰比AⅡ第一次升高的高峰出现得早。可能CA的增密是引起AⅡ增高的原因之一。 3 to 5 minutes after the injection of endotoxin, blood pressure was significantly decreased, plasma angiotensin Ⅱ (A Ⅱ) and catecholamine (CA) were increased, which may be due to lower blood pressure caused by the compensation. About 4 hours, blood pressure rose, A Ⅱ and CA are close to the control level, the animals are compensated. Pre-mortem blood pressure again reduced, A Ⅱ and CA increased again. The trends of AⅡ and CA were basically the same, but the peak of the first elevation of CA appeared earlier than the peak of the first increase of AⅡ. It is possible that CA encryption is one of the reasons that cause AII increased.