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钩吻水溶性总碱对大鼠血中胆碱酯酶有抑制作用。为进一步了解钩吻碱对内脏有无直接损害作用,对21只大鼠按每公斤体重灌胃0.3 ml水溶性钩吻碱,30分钟后将鼠处死取内脏进行病理组织学检查。大鼠钩吻水溶性总碱中毒后,引起大鼠心浊肿占28.6%、肺浊肿占61.9%、肝浊肿占85.7%、肾浊肿占100.0%,引起肠急性粘膜炎症19.0%、气管急性粘膜炎症66.7%,引起脾淤血占33.3%。钩吻水溶性总碱中毒除可抑制血中胆碱酯酶,使体内乙酰胆碱增高,抑制呼吸中枢和引起外周植物神经M样效应外,
Hydrochloride total alkaloids on rat blood cholinesterase inhibition. In order to further understand the effect of koumine alkaloids on the visceral injury, 21 rats were perfused with 0.3 ml of water-soluble benzalkonium chloride per kilogram of body weight. After 30 minutes, the rats were sacrificed and the viscera was taken for histopathological examination. Rat hook kissed water soluble total alkalosis, causing rat heart turbidity accounted for 28.6%, pulmonary turbidity accounted for 61.9%, liver turbidity accounted for 85.7%, kidney turbidity accounted for 100.0%, causing intestinal inflammation 19.0% Tracheal acute mucosal inflammation 66.7%, causing spleen congestion accounted for 33.3%. Kiss kiss water soluble total alkalosis in addition to inhibiting blood cholinesterase, so that the body increased acetylcholine, respiratory center and inhibit the respiratory M-induced peripheral nerve-like effect,