由于在实际现场上,防护日本血吸虫病感染所常用的皮肤防护药物(如皮避敌等),维持时间较短,我们于1973年对氯硝柳胺二甲亚砜皮肤涂擦的防护效果,进行了初步试验,得到了比较满意的防护效果(在实验室中1‰氯硝柳胺二甲亚砜溶液在12小时之内能完全保护小白鼠不受血吸虫尾蚴的感染)。但由于二甲亚砜成本较贵,在现场较难大规模推广使用。因此,我们又进一步进行了降低成本又不影响防护效果的试验,取得了一定的成效。在实验 Because in the actual scene, the protective skin protection drugs (such as skin and other anti-enemy) commonly used in the protection of schistosomiasis japonica, to maintain a shorter period of time, we in 1973 on niclosamide dimethyl sulfoxide skin rubbed protective effect, A preliminary test was carried out and a satisfactory protective effect was obtained. (In the laboratory, 1% niclosamide solution can completely protect mouse from infection with cercariae of Schistosoma japonicum within 12 hours). However, the more expensive dimethylsulfoxide, the more difficult to promote the use of the site. Therefore, we have further carried out the test of reducing the cost without affecting the protective effect and achieved some results. In experiment