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1 方法及结果 本院1987～1996年间收治NIDDM住院患者313例,其中记录完整并作了社会再适应评价(SRRS)问卷调查的276例,其中21例发生磺脲类药继发性失效(7.6％)。 21例中男6例,女15例,年龄46～64岁,平均53.4岁,磺脲类药物疗程3～11年,平均5.2年,严格控制饮食12例,不规则饮食控制9例,职业或退休前职业均为非体力劳动,生活习惯缺少运动,近期有间发病4例,为脑梗塞、胆石症、尿路感染和上消化道出血。社会再适应评价量表采用Holmes TH和Rahe RT创制,按国情略加修改,对患者进行问卷调查,全组276例得分75～138分,平均91.6分,磺脲类失效者为89～138分,平均103.5分。
Methods and Results A total of 313 hospitalized patients with NIDDM were enrolled in our hospital from 1987 to 1996. Among them, 276 cases were recorded as complete and were assessed by social re-fitness assessment (SRRS) questionnaire. Twenty-one of the 21 cases experienced secondary failure of sulfonylureas (7.6 %). 21 cases of 6 males and 15 females, aged 46 to 64 years old, an average of 53.4 years old, sulfonylurea treatment of 3 to 11 years, an average of 5.2 years, 12 cases of strict diet control, 9 cases of irregular diet control, occupation or Pre-retirement occupations are non-manual work, lack of exercise habits, recent cases of intercourse in 4 cases, for cerebral infarction, cholelithiasis, urinary tract infection and upper gastrointestinal bleeding. Social Re-accreditation Evaluation Scale Holmes TH and Rahe RT creation, a slight modification according to national conditions, the patient questionnaire survey, the whole group of 276 cases scored 75 to 138 points, an average of 91.6 points, sulfonylurea failure was 89 to 138 points , An average of 103.5 points.