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服用地高辛的10%病人,一部分地高辛可由肠管内细菌代谢。当投予抗生素引起肠管内细菌群变化时,可使地高辛的代谢减少,因而引起血中地高辛浓度上升。Lindenbaum 对3个健康的受试者,在22～29天中,连续每日投予地高辛,其中5天每日口服抗生素(四环素片或红霉素片)。结果,这些受试者,约40%的地高辛代谢均在肠管内进行。当投予抗生素后,无活性代谢物的生成减少,3个受试者的地高辛血药浓
Taking digoxin 10% of patients, some digoxin can be metabolized by intestinal bacteria. When antibiotics are administered to cause changes in the bacterial flora in the intestine, the metabolism of digoxin is reduced, resulting in an increase in the concentration of digoxin in the blood. Lindenbaum administered digoxin daily to three healthy volunteers for 22 to 29 days, with oral antibiotics (tetracycline tablets or erythromycin tablets) taken daily for 5 days. As a result, about 40% of digoxin metabolites were administered in the intestine in these subjects. When antibiotics were administered, the generation of inactive metabolites decreased, digoxin plasma concentrations in 3 subjects