一、前言大环内酯是最早使用的一类亲酯碱性抗生素类,在它的化学结构中具有一个大的内酯环。这类抗生素对革蓝氏阳性菌和支原体类均有很高的活性,因此对这类微生物引起的感染,口服有效。哺乳类用药后能特征的分布于肝、肺和脾且对呼吸道或胆道感染有 First, the introduction of macrolide is the first to use a class of pro-family of basic antibiotics, in its chemical structure has a large lactone ring. These antibiotics have high activity against both gram-positive and mycoplasma-type organisms and are therefore orally effective against infections caused by such microorganisms. Mammals can be characterized after drug distribution in the liver, lung and spleen and respiratory or biliary tract infections