论文部分内容阅读
目的 探讨一氧化氮 (NO)对糖尿病胃轻瘫患者体表胃电及食管蠕动的影响。方法 应用PCpolygrafHR高分辨多通道测压系统检测糖尿病患者的食管下括约肌压力 (LESP)、食管下括约肌长度 (LESL)及食管远端蠕动幅度等动力参数 ;应用Digitrapper动态胃电图仪监测糖尿病患者消化间期及消化期的体表胃电 (EGG)变化规律 ;并检测血清NO含量。结果 糖尿病组LESP ,LESL明显低于正常对照组 (P <0 .0 1) ,而病理性蠕动比例则显著高于正常对照组 (P <0 .0 1) ;与对照组比较 ,糖尿病患者MMCⅡ、Ⅲ期胃电功率明显减少 ,餐后 30分钟最显著 (均P <0 .0 1)。糖尿病组血清NO含量显著高于正常对照组 (P <0 .0 1) ;结论 Ⅱ型糖尿病胃轻瘫患者食管蠕动及胃电节律异常。NO可能参与糖尿病胃轻瘫及食管运动功能障碍的发病机制
Objective To investigate the effect of nitric oxide (NO) on gastric electrical activity and esophageal peristalsis in diabetic gastroparesis patients. Methods PCpolygraf HR high-resolution multi-channel manometry system was used to detect the dynamic parameters of the lower esophageal sphincter pressure (LESP), the length of the lower esophageal sphincter (LESL) and the distal esophageal peristalsis. Digitrapper dynamic electrogastrograph was used to monitor the digestive system of diabetic patients Interphase and digestive period of body surface electricity (EGG) changes; and detection of serum NO content. Results LESP and LESL in diabetic group were significantly lower than those in normal control group (P <0.01), but the proportion of pathological peristalsis was significantly higher than that in normal control group (P <0.01). Compared with control group, , And the gastric electrical power in stage Ⅲ decreased significantly (P <0.01). The serum NO level in diabetic group was significantly higher than that in normal control group (P <0.01). Conclusion The esophageal peristalsis and abnormal gastric electrical rhythm in type 2 diabetic patients with gastroparesis. NO may be involved in the pathogenesis of diabetic gastroparesis and esophageal dysfunction