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目的了解慢性前列腺炎(CP)与病原菌的关系以及病原菌的耐药状况。方法对门诊274例CP患者进行前列腺液(EPS)细菌培养并进行菌种鉴定和耐药性测试,结果根据NCCLS规定进行判断。结果在274份标本中,107例(39．1%)培养呈阳性,G~+菌占92．5%(99/107),G~-菌占7．5%(8/107)。其中金黄色葡萄球菌88株,占82．24%(88/107),远远高于其它菌种,检出耐甲氧西林金黄色葡萄球菌(MRSA)30株,占金黄色葡萄球菌的34．1%。MRSA对青霉素、苯唑西林、克林霉素、阿奇霉素、环丙沙星、庆大霉素,四环素的耐药率显著高于甲氧西林敏感金黄色葡萄球菌(MSSA)。没有发现耐万古霉素菌株。结论CP患者前列腺液中分离出的细菌以金黄色葡萄球菌为主,MRSA占相当高比例,呈多重耐药。在CP的治疗过程中要严格掌握抗生素使用指征,避免滥用抗生素。
Objective To understand the relationship between chronic prostatitis (CP) and pathogens and the drug resistance of pathogens. Methods Prostate fluid (EPS) was cultured in 274 outpatients with CP and tested for bacterial species and drug resistance. The results were judged according to the NCCLS rules. Results In 274 specimens, 107 (39.1%) were positive for culture, accounting for 92.5% (99/107) for G ~ + bacteria and 7.5% (8/107) for G ~ - bacteria. Among them, 88 strains of Staphylococcus aureus accounted for 82.24% (88/107), which was much higher than that of other strains. Thirty methicillin-resistant Staphylococcus aureus (MRSA) strains were detected, accounting for 34 .1%. The resistance rate of MRSA to penicillin, oxacillin, clindamycin, azithromycin, ciprofloxacin, gentamicin and tetracycline was significantly higher than that of methicillin-sensitive Staphylococcus aureus (MSSA). No vancomycin-resistant strains were found. Conclusions Staphylococcus aureus is the main bacterium isolated from prostatic fluid of CP patients. MRSA accounts for a relatively high proportion and is multi-drug resistant. In the course of the treatment of CP should strictly grasp the indications for the use of antibiotics, to avoid abuse of antibiotics.