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目的探讨CCR7在甲状腺乳头状微小癌中表达情况及其与甲状腺乳头状微小癌临床病理特征的关系。方法采用免疫组织化学S-P法检测31例甲状腺乳头状微小癌,34例直径>1 cm的甲状腺乳头状癌、34例结节性甲状腺肿以及12例甲状腺乳头状微小癌对侧正常甲状腺组织中CCR7的表达情况。结果 CCR7在甲状腺乳头状微小癌及直径>1 cm甲状腺乳头状癌中的表达阳性率均为100%,其差异无统计学意义(P>0.05),而在结节性甲状腺肿和正常甲状腺组织中CCR7的表达阳性率分别为64.7%和33.3%,与甲状腺乳头状微小癌相比差异有统计学意义(P<0.05)。CCR7的表达与患者性别、年龄、侵犯甲状腺被膜及淋巴结转移均无关(P>0.05)。结论 CCR7的表达在甲状腺乳头状微小癌和直径>1 cm甲状腺乳头状癌中均呈高表达,两者可能具有相同的生物学特性,两者均易发生颈淋巴结转移,均需要进行颈淋巴结(中央区)清扫。
Objective To investigate the expression of CCR7 in papillary thyroid carcinoma and its relationship with clinicopathological features of papillary thyroid carcinoma. Methods Immunohistochemical SP method was used to detect the expression of CCR7 in 31 cases of papillary thyroid carcinoma, 34 cases of thyroid papillary carcinoma> 1 cm in diameter, 34 cases of nodular goiter and 12 cases of thyroid papillary carcinoma. The expression of the situation. Results The positive rates of CCR7 expression in papillary thyroid carcinoma and papillary thyroid carcinoma> 1 cm in diameter were all 100%, with no significant difference (P> 0.05). However, in nodular goiter and normal thyroid tissue The positive rate of CCR7 expression was 64.7% and 33.3%, respectively, which was significantly different from papillary thyroid carcinoma (P <0.05). The expression of CCR7 had no correlation with the gender, age, invasion of thyroid gland and lymph node metastasis (P> 0.05). Conclusions The expression of CCR7 is highly expressed in papillary thyroid carcinoma and papillary thyroid carcinoma> 1 cm in diameter, both of which may have the same biological characteristics. Both of them are prone to cervical lymph node metastasis and require cervical lymph node metastasis Central District) cleaning.