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丙二醇二硝酸酯(简称PGDN)是混酯燃料的能源剂。Clark等)于1969年首先报导了PGDN在体内外的代谢转化,指出其主要代谢产物是2一丙二醇-硝酸酯(简称2-PGMN)和少量的Ⅰ-丙二醇一硝酸酯(简称1-PGMN),此过程主要在RBC内进行的。本工作试图用体外试验的方法进一步观察PGDN的代谢部位及其规律。
Propylene glycol dinitrate (PGDN) is an energy agent for blending ester fuels. Clark et al.) First reported the in vitro and in vivo metabolic transformation of PGDN in 1969, pointing out that its major metabolites are 2-propanediol-nitrate (abbreviation 2-PGMN) and a small amount of 1-propanediol mononitrate , This process is mainly carried out within the RBC. This work attempts to use in vitro methods to further observe the PGDN metabolic sites and their laws.