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早在1950年,Gold 就已发现洋地黄和奎尼丁合用时的毒性反应,并报道了2例洋地黄化病人给予较小剂量的奎尼丁(各为0.9克/日和1.2克/日),各于第四天及第五天发生暂时性心脏停搏,而单独应用同一剂量的奎尼丁或洋地黄则均不引起意外。但一直未引起临床上的重视,而错误地认为两药并用时所出现的各种毒性症状均为奎尼丁的中毒反应。近年来,由于开展了血浆狄戈辛浓度(PDC)的放射免疫测定,发现狄戈辛和奎尼丁合并应用后,奎尼丁可促使 PDC明显增加,并产生狄戈辛中毒反应,临床上才注意到两药合用后在人体内的相互作用。本文综述近年来的有关文献。临床发现1978年,Leahey 等在92名并用狄戈辛、奎尼丁的病人中,选择无肾功能不全、电解质紊乱、以及未合用其它抗心律失常药物
As early as 1950, Gold found toxic effects of digitalis and quinidine in combination and reported that two patients with digitalis were given smaller doses of quinidine (0.9 g / day and 1.2 g / day respectively) ), Each on the fourth and fifth days of temporary cardiac arrest, and the same dose of quinidine alone or digitalis were not caused by accidents. But has not caused clinical attention, but mistakenly believe that the two drugs used in combination with various toxic symptoms are quinidine poisoning. In recent years, due to the implementation of the plasma Dioxin concentration (PDC) radioimmunoassay and found that the combination of Digoxin and quinidine, the application of quinidine can significantly increase the PDC, and produce digoxin toxicity, the clinical attention To the two drugs combined in the human body after the interaction. This article summarizes the relevant literature in recent years. Clinical findings In 1978, Leahey and other 92 patients with Dioxin Xin, quinidine, choose no renal insufficiency, electrolyte imbalance, and not with other anti-arrhythmic drugs