血管紧张素转换酶抑制剂硫甲丙甫酸(Captopril)治疗高血压和充血性心衰已有文献报道,但对心肌梗塞有何影响尚未报道。因为结扎冠状动脉,可以激活肾素、血管紧张素系统,导致心肌缺血损伤的扩大和加重,所以推测巯甲丙甫酸对梗塞心肌细胞可能具有一定的保护作用。 材料与方法一,大鼠心肌梗塞模型的制备 Angiotensin converting enzyme inhibitor Captopril has been reported in the literature for the treatment of hypertension and congestive heart failure. However, the impact of captopril on myocardial infarction has not been reported. Because ligation of the coronary arteries, can activate the renin, angiotensin system, leading to the expansion and aggravate of myocardial ischemic injury, speculated that captopril may have some protective effect on infarcted cardiomyocytes. Materials and methods First, the preparation of rat myocardial infarction model