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目的探究小剂量尿激酶溶栓联合抗凝治疗中危肺栓塞合并下肢深静脉血栓的疗效。方法 62例中危肺栓塞合并下肢深静脉血栓患者,随机分成观察组和对照组,各31例。对照组给予常规低分子肝素序贯华法林抗凝治疗,观察组在对照组治疗基础上实行小剂量尿激酶溶栓治疗。观察两组治疗3、14 d的临床症状缓解率、血栓治疗情况。结果治疗3 d后,观察组呼吸困难、胸痛缓解率高于对照组(P<0.05)。治疗14 d后,观察组咳嗽缓解率高于对照组(P<0.05)。观察组下肢血栓治疗总有效率为54.84%,高于对照组的32.26%(P<0.05)。结论中危肺栓塞合并下肢深静脉血栓通过小剂量尿激酶溶栓、抗凝治疗,临床效果较好,且安全、可靠。
Objective To investigate the efficacy of low-dose urokinase thrombolytic therapy in combination with anticoagulation for the treatment of moderate-risk pulmonary embolism combined with deep vein thrombosis. Methods Sixty-two patients with moderate-risk pulmonary embolism complicated with deep venous thrombosis of lower extremities were randomly divided into observation group and control group, with 31 cases in each group. Control group was given conventional low molecular weight heparin sequential warfarin anticoagulant therapy, the observation group in the control group based on the implementation of low-dose urokinase thrombolytic therapy. The clinical symptoms remission rate and thrombosis of the two groups were observed 3 and 14 days after treatment. Results After 3 days of treatment, the observation group had dyspnea and chest pain relief rate higher than that of the control group (P <0.05). After 14 days of treatment, the relief rate of cough in observation group was higher than that in control group (P <0.05). The total effective rate of lower extremity thrombosis in observation group was 54.84%, higher than that in control group (32.26%, P <0.05). Conclusions The moderate-risk pulmonary embolism combined with deep venous thrombosis of lower extremity through thrombolysis with low-dose urokinase and anticoagulant therapy has good clinical effect and is safe and reliable.