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Phosphorylation is a key reversible modification of proteins that acts as a switch to regulate almost all biological processes.Phosphoproteomics analysis aims to identify and characterize all the protein phosphorylations presented in cells or tissues.Conventional adsorbents for phosphopeptide enrichment lack enough specificity,which seriously compromises the performance of phosphoproteome analysis.The research lab headed by Prof.Zou Hanfa in CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences(CAS)developed a new type of immobilized metal ion affinity chromatography(IMAC)adsorbent for highly specific enrichment of phosphopeptides in phosphoproteomics analysis.The schematics for this new IMAC are shown in the Figure below.The phos-
Phosphorylation is a key reversible modification of proteins that acts as a switch to regulate almost all biological processes. Phosphoproteomics analysis aims to identify and characterize all the protein phosphorylations presented in cells or tissues. Conventional adsorbents for phosphopeptide enrichment lack enough specificity, which seriously compromises the performance of phosphoproteome analysis. the research lab headed by Prof. Zou Hanfa in CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS) developed a new type of immobilized metal ion affinity chromatography (IMAC ) adsorbent for highly specific enrichment of phosphopeptides in phosphoproteomics analysis. The schematics for this new IMAC are shown in the Figure below. The phos-