Amyloidosis is a multisystem disease that is character-ized by deposition of fibrils in extracellular tissue,which mainly involves the kidney,heart,and autonomic nervous system.Two types of amyloidosis typically infiltrate the heart,including immunoglobulin light-chain(AL)and amyloid transthyretin(ATTR).ATTR is further subdivided into wild-type ATTR and variant ATTR caused by point mutations in the TTR gene.[1]Wild-type ATTR is consid-ered as not uncommon in older patients with heart failure.Recently,a comprehensive set of consensus recommenda-tions for the suspicion and diagnosis of ATTR was pub-lished,with particular focus on the combined application of noninvasive methods.[2]We present here a case of wild-type TTR cardiac amyloidosis(ATTRwt-CA),which was diag-nosed by noninvasive modalities,and provide an overview of the recommended diagnostic approach of CA.Further-more,to the best of our knowledge,this is the first Chinese case of ATTRwt-CA reported to date.