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目的探讨脂肪肝与代谢异常的关系,为预防脂肪肝提供依据。方法选取煤炭企业职工脂肪肝人群841例作为研究对象,另选取无脂肪肝的802例健康体检人群作为对照组,检测空腹血糖、血脂、尿酸、谷丙转氨酶等生化指标,测量血压,计算体重指数,对结果进行分析。结果脂肪肝组的总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹血糖、尿酸、谷丙转氨酶、血压、体重指数水平显著高于非脂肪肝组(P<0.01);高密度脂蛋白胆固醇水平显著低于非脂肪肝组(P<0.01)。且随着脂肪肝程度的加重,TC、TG、LDL-C、FBG、UA、ALT、BMI、SBP和DBP水平呈逐渐上升的趋势,HDL-C水平呈逐渐下升的趋势,差异有统计学意义(P<0.01或P<0.05)。结论脂肪肝患者易伴发各种代谢异常,脂肪肝对肝功能(ALT)造成一定的损伤。
Objective To investigate the relationship between fatty liver and metabolic abnormalities and provide basis for preventing fatty liver. Methods A total of 841 fatty liver patients in coal enterprises were selected as the research objects. Another 802 healthy people without fatty liver were selected as the control group, and the biochemical indexes such as fasting blood glucose, blood lipid, uric acid and alanine aminotransferase were measured, blood pressure was measured, body mass index , The results of the analysis. Results The levels of total cholesterol, triglyceride, low density lipoprotein cholesterol, fasting blood glucose, uric acid, alanine aminotransferase, blood pressure and body mass index in steatohepatitis group were significantly higher than those in non-steatohepatitis group (P <0.01). High density lipoprotein cholesterol The level was significantly lower than non-fatty liver group (P <0.01). The levels of TC, TG, LDL-C, FBG, UA, ALT, BMI, SBP and DBP increased gradually along with the degree of fatty liver, while the level of HDL-C showed a gradually decreasing trend Significance (P <0.01 or P <0.05). Conclusion Patients with fatty liver are easily accompanied by various metabolic abnormalities. Fatty liver may cause some damage to liver function (ALT).