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干扰素敏感决定区(ISDR)的准种特性与干扰素的疗效密切相关。体外研究发现,野生型的丙型肝炎病毒(HCV)非结构蛋白5A(NS5A)能与干扰素(内源或外源的)诱导的双链RNA依赖的蛋白激酶(PKR)结合并相互作用,从而抑制PKR的抗病毒活性。部分揭示了NS5A与HCV持续感染的
Quasi-species characteristics of interferon-sensitive determinant (ISDR) are closely related to the efficacy of interferon. In vitro studies revealed that the wild-type hepatitis C virus (HCV) nonstructural protein 5A (NS5A) binds and interacts with interferon (endogenous or exogenous) -induced double-stranded RNA dependent protein kinase (PKR) Thus inhibiting the antiviral activity of PKR. Partially revealed persistent NS5A and HCV infection