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目的:分析比较口服丙戊酸(Valproate,VPA)和托吡酯(Topiramate,TPM)对癫癎患者长程视频脑电图的影响。方法:对152例单独应用丙戊酸和129例单独应用托吡酯至少两年无发作的癫癎患者脑电图进行分析和比较,所有患者进行至少2次24小时长程视频脑电图检查,期间间隔至少2年。结果:结果:丙戊酸钠组,136例患者癫癎发作波明显减少或消失,15例患者癫癎发作波无明显减少,1例患者癫癎发作波增加;托吡酯组,112例患者癫癎发作波明显减少或消失,16例患者癫癎发作波无明显减少,1例患者癫癎发作波增加。两组比较,差异无统计学意义。结论 :丙戊酸钠和托吡酯均可使症状性癫癎或原发性癫癎的临床发作得到控制,与脑电图的改变基本一致。
Objective: To analyze the effects of oral administration of valproate (VPA) and topiramate (TPM) on long-term video EEG in patients with epilepsy. Methods: 152 patients with valproic acid alone and 129 patients with topiramate alone for at least two seizures in epileptic patients were analyzed and compared, all patients at least 2 24 hours long-range video EEG, interval At least 2 years. Results: In the sodium valproate group, epileptic seizure wave significantly decreased or disappeared in 136 patients, no significant reduction in epileptic seizure wave occurred in 15 patients, and epileptic seizure wave was increased in 1 patient. In the topiramate group, 112 patients with epilepsy Seizure wave significantly reduced or disappeared, 16 patients with epileptic seizures no significant reduction in wave, 1 patient increased epileptic seizure wave. The two groups, the difference was not statistically significant. Conclusion: Both sodium valproate and topiramate can control the clinical seizures of symptomatic epilepsy or primary epilepsy, which is consistent with the change of EEG.