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糖皮质激素(简称激素一下同)的隔日疗法,是临床治疗学上的一个重要进展,尤其适用于需用激素进行中程和长程治疗的疾病。实践证明,隔日疗法是一种既可收到临床上预期的治疗效果,又可最大程度地减少副作用和并发症的较理想的给药方法。本文仅对隔日疗法的理论、用法及注意事项等略加概述,供参考。理论基础糖皮质激素是由肾上腺皮质所分泌的。其分泌活动由丘脑下部、垂体和糖皮质激素本身在血液中的浓度来调节,当血中激素的浓度达到一定水平时,能反馈性地抑制垂体-肾上腺皮质的分泌,从而减少血中激素的浓度。近年来通过对尿和血浆中17-羟皮质类固醇的测定,了解到正常人的肾上腺皮质的分泌活动还有着明显的昼夜间的规律性变化。即白天工作夜间休息
Glucocorticoids (hereinafter referred to as the same hormones) the next day therapy is an important progress in clinical therapeutics, especially for the need to use hormones for medium and long-term treatment of diseases. Practice has proved that the next day therapy is a can receive clinically expected therapeutic effect, but also to minimize the side effects and complications of the more ideal method of administration. This article only for the second day of therapies theory, usage and precautions such as a brief overview for reference. Theoretical Basis Glucocorticoid is secreted by the adrenal cortex. Its secretory activity by the hypothalamus, pituitary and glucocorticoid itself in the blood to regulate the concentration, when the blood hormone concentration reaches a certain level, can inhibit the secretion of pituitary-adrenal cortex, thereby reducing the blood hormone concentration. In recent years through the determination of urine and plasma 17-hydroxy corticosteroids, learned that normal human adrenal cortical secretion activity there is a clear regular changes in day and night. That is, working daytime rest during the day