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目的探讨老年T2DM患者无症状菌尿(ASB)现状及危险因素。方法选取2011年1月至2012年12月于我科住院的无尿路刺激征的老年T2DM患者632例,收集基线资料。未干预状态下检测FPG、2 hPG、HbA_1c和尿培养结果。结果 T2DM组年龄、FPG、2 hPG、HbA_1c低于T2DM合并ASB组(P<0.05)。老年T2DM患者ASB发生率为23.58%,男性和女性的发生率分别为16.29%、30.46%,两者比较,差异有统计学意义(P<0.01);共检出149株阳性菌株,大肠埃希菌占52.35%。Logistic回归分析显示,性别(β=0.782,P=0.0003)、年龄(β=0.040,P=0.0122)及FPG(β=0.083,P=0.0061)是老年T2DM患者发生ASB的独立危险因素。结论老年T2DM患者发生ASB与女性、年龄、FPG相关;ASB的菌群以革兰氏阴性杆菌为主,大肠埃希菌占首位。
Objective To investigate the status and risk factors of asymptomatic bacteriuria (ASB) in elderly patients with T2DM. Methods 632 elderly T2DM patients without urinary tract irritation hospitalized in our department from January 2011 to December 2012 were selected and baseline data were collected. FPG, 2 hPG, HbA_1c and urine culture results were measured without intervention. Results The age, FPG, 2 hPG and HbA_1c in T2DM group were lower than those in T2DM and ASB group (P <0.05). The incidence of ASB in elderly T2DM patients was 23.58%, the incidence rates of male and female were 16.29% and 30.46%, respectively. The difference was statistically significant (P <0.01). A total of 149 positive strains were detected, including Escherichia coli The bacteria accounted for 52.35%. Logistic regression analysis showed that ASB was an independent risk factor for ASB in elderly patients with T2DM in terms of sex (β = 0.782, P = 0.0003), age (β = 0.040, P = 0.0122) and FPG (β = 0.083, P = 0.0061) Conclusions The occurrence of ASB in elderly patients with T2DM is related to the age of female and FPG. The bacteria of ASB are mainly Gram-negative bacilli and Escherichia coli is the most common.