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目的 研究老年肺部感染患者生长激素胰岛素样生长因子轴(GH -IGF轴)的变化及其与蛋白代谢的关系。方法 检测2002-07~2003-01首都医科大学宣武医院老年科和急诊科的20例老年肺部感染患者的血清生长激素(GH)、胰岛素样生长因子Ⅰ(IGF -Ⅰ)、胰岛素样生长因子结合蛋白1 (IGFBP -1 )、胰岛素样生长因子结合蛋白3 (IGFBP -3)、总蛋白、白蛋白、前白蛋白、转铁蛋白的质量浓度,并与老年正常对照组相比。结果 (1)肺部感染患者的血清IGF- Ⅰ质量浓度显著低于正常对照组(P<0 .05),而血清GH、IGFBP- 1质量浓度显著高于对照组(P<0 .05); (2)肺部感染患者的血清总蛋白、白蛋白、前白蛋白、转铁蛋白的质量浓度显著低于正常对照组(P<0. 01); (3)血清GH、IGF -Ⅰ、IGFBP- 1、IGFBP -3与血清白蛋白、前白蛋白、转铁蛋白之间呈相关关系。结论 老年肺部感染患者存在着GH -IGF轴的变化,此变化与蛋白代谢相关。
Objective To study the changes of growth hormone insulin-like growth factor axis (GH-IGF axis) and its relationship with protein metabolism in elderly patients with pulmonary infection. Methods The serum levels of growth hormone (GH), insulin-like growth factor (IGF-Ⅰ), insulin-like growth factor (IGF-Ⅰ) in 20 elderly patients with pulmonary infection in the geriatric and emergency department of Xuanwu Hospital of Capital Medical University from July 2002 to January 2003 were detected. IGFBP-1, IGFBP-3, total protein, albumin, prealbumin and transferrin, and compared with the normal control group of the elderly. Results (1) Serum IGF-Ⅰ concentration in patients with pulmonary infection was significantly lower than that in the normal control group (P <0.05), while serum GH and IGFBP-1 concentrations were significantly higher than those in the control group (P0.05) ; (2) The serum concentrations of total protein, albumin, prealbumin and transferrin in patients with lung infection were significantly lower than those in normal control group (P <0.01); (3) Serum GH, IGF- IGFBP-1, IGFBP-3 and serum albumin, prealbumin, transferrin correlation between. Conclusion There is a change of GH-IGF axis in elderly patients with pulmonary infection, which is related to protein metabolism.