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目的 观察鼻咽癌患者全血硒和谷胱甘肽过氧化物酶(GSH—PX)的水平与健康人群差别及临床意义。方法 硒测定单用DNA荧光法,血GSH—PX采用2—硝基苯甲酸,DTNB直接显色法。设二组研究(健康人群76例和鼻咽癌患者198例)。结果 ①鼻咽癌患者放疗前血硒和GSH—PX水平均低于对照组(P<0.001)。②鼻咽癌患者经治疗后,血硒和GSH—PX活性水平略有提高,但较健康人群为低,治疗前后经均数t检验均无显著差异(P>0.05)。结论 ①临床上应用硒制剂对低硒水平的癌症患者可能有益。②血硒和GSH—PX活性水平与鼻咽癌患者发展及预后有关,动态观察血硒及GSH—PX活性水平有助于临床判断预后。
Objective To observe the difference and clinical significance of serum levels of selenium and glutathione peroxidase (GSH-PX) in healthy people from patients with nasopharyngeal carcinoma. Methods Selenium determination alone DNA fluorescence method, blood GSH-PX using 2-nitrobenzoic acid, DTNB direct colorimetric method. Set two groups of studies (76 healthy subjects and 198 patients with nasopharyngeal carcinoma). Results ① The blood levels of selenium and GSH-PX in patients with nasopharyngeal carcinoma before radiotherapy were lower than those in the control group (P <0.001). ② After treatment, the levels of selenium and GSH-PX in sera of patients with nasopharyngeal carcinoma increased slightly, but were lower than those in healthy subjects. There was no significant difference between before and after treatment (P> 0.05). Conclusions ① Clinical application of selenium preparations may be beneficial for cancer patients with low selenium level. ② The levels of blood selenium and GSH-PX activity were correlated with the development and prognosis of patients with nasopharyngeal carcinoma. The dynamic observation of selenium and GSH-PX activity could be helpful to predict the prognosis.