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目的:通过Meta分析,对颊黏膜鳞状细胞癌(颊癌)在单纯局部扩大切除和附加颈部处理、单纯手术和术后辅助放疗情况下的治疗结果分别进行系统评价,从而对这些不同治疗方法的效果作出比较。方法:以“颊黏膜”、“鳞状细胞癌”、“治疗”、“手术”、“颈淋巴清扫术”、“放疗”、“化疗”、“综合治疗”和“预后”为关键词,检索PubMed、Cochrane图书馆临床对照试验注册资料库、中国知网(CNKI)和维普电子期刊网,按纳入和排除标准筛选文献,从入选文献中提取相应数据进行Meta分析。结果:检出文献118篇,入选11篇。用RevMan4.2.10软件分别计算单纯局部扩大切除和附加颈部处理、单纯手术和术后辅助放疗情况下复发率的相对危险度、生存率的优势比以及相关统计学检验数值。结论:早中期颊癌患者,建议同期行颈淋巴清扫术;中晚期颊癌患者,应常规行同期颈淋巴清扫术及术后放疗;pN+以及切缘阳性患者,应常规行同期颈淋巴清扫术及术后放疗。
OBJECTIVE: To systematically evaluate the results of the treatment of buccal mucosal squamous cell carcinoma (buccal carcinoma) by simple local enlargement and excision with neck treatment, simple surgery and postoperative adjuvant radiotherapy through meta-analysis, so that these different treatments The effect of the method is compared. Methods: The patients were treated with “buccal mucosa”, “squamous cell carcinoma”, “treatment”, “surgery”, “neck dissection”, “radiotherapy” PubMed, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), and Vip Electronic Journals, to select the literature by inclusion and exclusion criteria , Extracted from the selected literature data for meta-analysis. Results: 118 papers were found and 11 papers were selected. The RevMan 4.2.10 software was used to calculate the relative risk of recurrence, survival odds ratio and related statistical test values in the cases of simple local enlargement resection and additional neck treatment, surgery alone and postoperative adjuvant radiotherapy. Conclusions: Cervical lymphadenectomy is recommended in patients with early or mid-term buccal carcinoma. Cervical lymphadenectomy and postoperative radiotherapy should be routinely performed in patients with advanced and late stage buccal carcinoma. Patients with positive pN + and positive margins should undergo routine neck dissection And postoperative radiotherapy.