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目的探究尽早溶栓在心肌梗死治疗中的效果与作用。方法选取2013年5月~2015年5月收治的急性心肌梗死患者144例作为研究对象,按患者就诊的时间将其分为四组,各36例。在发病3 h内溶栓治疗的为A组,发病3~6 h内溶栓治疗的为B组,发病6~12 h内溶栓治疗的为C组,发病在12 h以上的为D组,所有患者均采用尿激酶进行溶栓治疗,统计四组患者冠脉再通率以及死亡率,比较四组患者的溶栓效果。结果 A组患者冠脉再通率为83.3%,显著高于B组的44.4%,C组的22.2%,D组的11.1%,差异均有统计学意义(P<0.05)。A组死亡率为5.6%,显著低于B组的22.2%,C组的16.7%,D组的22.2%,差异均有统计学意义(P<0.05)。四组肌酸磷酸激酶(CPK)峰值时间、肌酸激酶同工酶(CK-MB)峰值时间均呈现递增趋势,A组患者CPK峰值时间、CK-MB峰值时间显著短于B、C、D组,差异均有统计学意义(P<0.05)。结论在治疗急性心肌梗死的过程中,尽早溶栓能够帮助改善患者的预后,降低患者的死亡率,对于患者的康复有重要的意义。
Objective To investigate the effect and role of early thrombolysis in the treatment of myocardial infarction. Methods A total of 144 patients with acute myocardial infarction who were admitted from May 2013 to May 2015 were selected as study subjects and divided into four groups according to the time of their visit. Within 3 h after onset of thrombolytic therapy for the A group, the incidence of 3 ~ 6 h thrombolytic therapy for the B group, the incidence of 6 ~ 12 h thrombolytic therapy for the C group, the incidence of more than 12 h for the D group , All patients were treated with urokinase for thrombolysis. The recanalization rate and mortality of coronary artery were calculated in four groups. The thrombolytic effect was compared between the four groups. Results The coronary recanalization rate in group A was 83.3%, which was significantly higher than that in group B 44.4%, group C 22.2% and group D 11.1% (P 0.05). The death rate in group A was 5.6%, which was significantly lower than that in group B (22.2%), group C (16.7%) and group D (22.2%) (P <0.05). The peak time of creatine phosphokinase (CPK) and the peak time of creatine kinase (CK-MB) showed an increasing trend in all four groups. The peak CPK time and the peak CK-MB time of group A were significantly shorter than those of group B, C and D Group, the difference was statistically significant (P <0.05). Conclusion In the treatment of acute myocardial infarction, as soon as possible thrombolysis can help improve the prognosis of patients and reduce the mortality of patients, for the rehabilitation of patients is of great significance.