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对近15年收治158例风湿热[含急性风湿热(ARF)136例及风湿性心脏病(RHD)22例]患儿的临床资料进行分析。结果表明,80年代以来,风湿热发病从未间断,近5年有增加趋势(83/158,52.5%)。136例ARF中96例(70.6%)出现心脏炎,以隐匿型心脏炎诊断者17例,占17.7%(17/96),余79例(82.3%)为典型急性心脏炎;慢性RHD22例,其瓣膜损害以二尖瓣关闭不全(MI)多见(68.2%,15/22),均合并慢性充血性心力衰竭(CHF);死亡3例,其中2例合并感染性心内膜炎(IE)、脑栓塞、呼吸衰竭死亡,1例因难治性CHF、淤血性肝硬化致肝功能衰竭、肝性脑病死亡。住院期间,ARF患儿,经正规治疗,尤其大剂量较长疗程(1~2月)青霉素静注,严格卧床休息及控制CHF等对症处理,50.0%患儿抗"O"下降或正常,49.1%患儿心脏杂音减轻或消失。认为,坚持长期、规律地药物预防复发及防治IE是降低RHD发生率和病死率的有效措施。
The clinical data of 158 cases of rheumatic fever (including 136 cases of acute rheumatic fever (ARF) and 22 cases of rheumatic heart disease (RHD)] were analyzed in the past 15 years. The results show that since the 1980s, the incidence of rheumatic fever has never stopped, the trend has increased in the past 5 years (83/158, 52.5%). Cardiac inflammation occurred in 96 cases (70.6%) in 136 cases of ARF, 17 cases (17/96) in diagnosis of occult cardiitis, and 79 cases (82.3%) in typical acute heart Inflammation; chronic rhinitis in 22 cases, the valve damage to mitral regurgitation (MI) more common (68.2%, 15/22), were associated with chronic congestive heart failure (CHF); 3 died, of which 2 were merged Infective endocarditis (IE), cerebral embolism, respiratory failure death, 1 case of refractory CHF, liver cirrhosis caused by liver failure, hepatic encephalopathy death. During hospitalization, ARF children, formal treatment, especially large doses of a longer course (January to February) penicillin intravenous injection, strict bed rest and control CHF and other symptomatic treatment, 50.0% of children with anti-“O” decline or normal , 49.1% of children with heart murmur to reduce or disappear. That, adhere to long-term, regular prevention and treatment of drug relapse and prevention of IE is to reduce the incidence of RHD and mortality effective measures.