以正常大鼠为实验对象，观察单纯外用花椒毒内酯，结香甲素，连续给药7d，致骨髓细胞染色体畸变率相应各达2％及0．2％。两者比较具显著性差异（P＜0．01）。结合UV－N辐照，给药1周，花椒毒内酯组致染色体畸变率为6．0％，结香甲素组为1．0％（P＜0．001）；治疗2周则分别为4．0％、2．0％（P＜0．05）均呈显著性差异。实验表明在光化学疗法中，花椒毒内酯外搽有明显的致诱变毒性，而结香甲素具有明显的抗诱变作用。 Using normal rats as subjects, the effect of topical administration of zanthoxyglucosadiotide and schizontidine for continuous administration for 7 days resulted in a chromosomal aberration of bone marrow cells of 2% and 0.2%, respectively. There was a significant difference between the two (P<0.01). Combined with UV-N irradiation, one week after administration, the frequency of chromosomal aberrations caused by the zanthoxylactone group was 6.0%, and 1.0% in the caseinoid group (P<0.001); There were significant differences between 4.0% and 2.0% (P<0.05). Experiments show that in the photochemotherapy, Zanthoxyglycan external carp has obvious mutagenic toxicity, and knot A has obvious antimutagenic effect.