含手性中心的药学活性物质往往以对映体成对存在 ,它们的物理性质相同 ,但分子构象不同 ,由于对映体中往往只有一种具有生物活性或药学相关性 ,对映体的分离成为制药工业的关键。外消旋化合物可通过结晶法 (过饱和、蒸馏 )、光学活性溶剂或热力学等方法分离 ,当目标化合物具有 Pharmacologically active substances containing chiral centers tend to exist in pairs as enantiomers, and their physical properties are the same, but their molecular conformations are different. Since only one enantiomer is biologically active or pharmacologically relevant, enantiomeric separation The key to the pharmaceutical industry. Racemic compounds can be isolated by crystallization (supersaturation, distillation), optically active solvents or thermodynamics, etc. When the target compound has