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目的运用ROC曲线评估IL-6对轻症肺炎中支原体感染的诊断意义。方法收集2011年1月-2013年6月宁波市鄞州人民医院收治的轻症支气管肺炎患儿200例,其中支原体肺炎患儿92例,非支原体肺炎患儿108例,健康体检儿童30例作为健康对照组,所有研究对象分别检查WBC、IL-6、CRP及相关临床指标,并用ROC曲线对IL-6的诊断效果进行评估。结果所有患儿中支原体肺炎的发病率为46%,急性期支原体肺炎患儿IL-6水平较非支原体肺炎及健康对照组明显升高,差异有统计学意义(P<0.05);ROC曲线下面积为0.78(95%可信区间:0.63~0.93),IL-6最佳诊断临界值为3.55 ng/ml,其诊断灵敏度和特异度分别为76.2%和73.3%。结论对急性期入院的轻症肺炎患儿IL-6水平进行检测,有助于早期诊断支原体感染,优于目前临床上所应用的CRP、WBC等炎症参数。
Objective To evaluate the diagnostic value of IL-6 in the diagnosis of mycoplasma infection in mild pneumonia by ROC curve. Methods A total of 200 children with mild bronchopneumonia admitted to Ningbo Yinzhou People’s Hospital from January 2011 to June 2013 were recruited. Among them, 92 were children with mycoplasmal pneumonia, 108 were children with non-mycoplasmal pneumonia and 30 were healthy children Control group, all subjects were examined WBC, IL-6, CRP and related clinical indicators, and the use of ROC curve to assess the diagnostic efficacy of IL-6. Results The incidence of mycoplasma pneumonia in all children was 46%. The level of IL-6 in children with acute mycoplasma pneumonia was significantly higher than that in non-mycoplasma pneumonia and healthy controls (P <0.05). The ROC curve With an area of 0.78 (95% confidence interval: 0.63-0.93). The best diagnostic threshold for IL-6 was 3.55 ng / ml, with diagnostic sensitivity and specificity of 76.2% and 73.3%, respectively. Conclusion The detection of IL-6 in children with acute pneumonia admitted in acute stage is helpful for the early diagnosis of mycoplasma infection, which is superior to the clinical parameters such as CRP and WBC.