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目的评价复方甘草酸苷联合阿昔洛韦治疗带状疱疹的有效性和安全性。方法检索CNKI、万方、维普数据库及Pub Med、The Cochrane Library关于复方甘草酸苷联合阿昔洛韦治疗带状疱疹的随机对照试验(RCT)。结果分析共纳入23个RCT,涉及1 669例带状疱疹患者。复方甘草酸苷联合阿昔洛韦治疗带状疱疹在治疗总有效率、疼痛缓解时间、止痛时间、结痂时间、止疱时间、痊愈时间和后遗神经痛发生情况等指标方面均明显优于单用阿昔洛韦治疗。结论复方甘草酸苷联合阿昔洛韦治疗带状疱疹的总体疗效优于单用阿昔洛韦,但由于研究存在一定的局限性,研究结果仍需要更多的多中心、大样本、双盲的高质量RCT支持。
Objective To evaluate the efficacy and safety of compound glycyrrhizin combined with acyclovir in the treatment of shingles. Methods CNKI, Wanfang, VIP databases and Pub Med, The Cochrane Library randomized controlled trials (RCTs) on the treatment of shingles with compound glycyrrhizin and acyclovir. Results Analysis A total of 23 RCTs were included, involving 1 669 patients with shingles. Compound glycyrrhizin combined with acyclovir in the treatment of shingles in the treatment of total effective rate, pain relief time, pain relief time, scab time, blister time, recovery time and the occurrence of post-nociceptive indicators were significantly better than Acyclovir alone treatment. Conclusion The overall efficacy of compound glycyrrhizin combined with acyclovir in the treatment of herpes zoster is better than that of acyclovir alone. However, due to the limitations of the study, the results still need more multicentre, large sample, double-blind High quality RCT support.