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目的 研究前列腺非典型腺瘤性增生(AAH)的诊断和鉴别诊断.方法 以10个病例13个病灶为对象,采用HE和免疫组化染色,显微镜下观察和测量.结果 AAH病灶的范围从48至285个腺泡,腺泡小,多呈圆形,排列紧密.腺泡被覆单层细胞,核均有轻度的多形性,核仁的平均直径0.66～0.72um.病灶的边缘整齐.免疫组化CK34βE12染色显示,部分腺泡的基底细胞层不完整.结论 AAH具有特定的形态学诊断标准,CK34βE12在鉴别诊断中具有重要作用,AAH的主要临床意义是与前列腺癌的鉴别诊断.
Objective To study the diagnosis and differential diagnosis of atypical adenomatous hyperplasia (AAH) in the prostate.Methods Thirteen lesions of 10 cases were studied by HE staining and immunohistochemistry staining.Results The range of AAH lesions ranged from 48 To 285 acinar, acinar small, mostly round, arranged in close acinar monolayer cells, the nucleus are mild pleomorphism, the average diameter of the nucleolus 0.66 ~ 0.72um. The edge of the neat lesions. Immunohistochemical staining of CK34βE12 showed that basal cell layers of some acinar cells were incomplete.Conclusion AAH has specific morphological diagnostic criteria, and CK34βE12 plays an important role in differential diagnosis. The main clinical significance of AAH is its differential diagnosis with prostate cancer.