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精子生成障碍是男性不育的主要原因之一,而无精症和少精症在男性不育症患者中,90%是由于生精功能障碍引起,其中特发性生精障碍占60%。近年来通过人类基因组计划的实施,发现不少Y染色体上诱发不育症的候选基因,包括类热休克蛋白因子HSFY、LW-1和mHSFYL。本文通过HSFY、LW-1和mHSFYL的编码特征,阐述它们在精子生成过程中的作用和诱发生精障碍、导致无精症和少精症的遗传学机理。
Spermatogenesis disorder is one of the main causes of male infertility, and azoospermia and oligozoospermia in male infertility, 90% is due to spermatogenic dysfunction, of which 60% of idiopathic spermatogenesis disorders. In recent years, through the implementation of the Human Genome Project, many candidate genes that induce infertility on Y chromosome have been found, including HSFY, LW-1 and mHSFYL. In this paper, the coding features of HSFY, LW-1 and mHSFYL are introduced to elucidate the roles of HSFY, LW-1 and mHSFYL in the process of spermatogenesis and the genetic mechanisms that induce spermatogenic disorders and lead to azoospermia and oligozoospermia.