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目的:探讨三氧化二砷治疗急性早幼粒细胞白血病高甘油三酯血症临床效果。方法:将2007年1月-2017年1月76例急性早幼粒细胞白血病患者作为研究对象根据方法分组,各有38例。对照组采用常规方法,三氧化二砷组在对照组基础上增加三氧化二砷治疗。比较两组急性早幼粒细胞白血病治疗效果;外周血指标恢复正常时间;治疗前后患者血清甘油三酯水平。结果:三氧化二砷组急性早幼粒细胞白血病治疗效果优于对照组,P<0.05;三氧化二砷组外周血指标恢复正常时间短于对照组,P<0.05;治疗前两组血清甘油三酯水平相近,P>0.05;治疗后三氧化二砷组血清甘油三酯水平高于对照组,P<0.05。结论:三氧化二砷治疗急性早幼粒细胞白血病临床效果确切,但可导致甘油三酯水平提高,需注意给予血脂调节和心脏保护药物。
Objective: To investigate the clinical effect of arsenic trioxide in the treatment of acute promyelocytic leukemia hypertriglyceridemia. Methods: From January 2007 to January 2017, 76 patients with acute promyelocytic leukemia were divided into groups according to the method, each with 38 cases. The control group using conventional methods, arsenic trioxide in the control group based on the addition of arsenic trioxide treatment. The therapeutic effects of acute promyelocytic leukemia in two groups were compared; the indexes of peripheral blood returned to normal; the levels of serum triglyceride in patients before and after treatment were compared. Results: Arsenic trioxide group of acute promyelocytic leukemia treatment effect is better than the control group, P <0.05; Arsenic trioxide group peripheral blood parameters returned to normal time was shorter than the control group, P <0.05; before treatment, serum triglyceride levels were similar, P > 0.05. After treatment, serum triglyceride level of arsenic trioxide group was higher than that of the control group (P <0.05). CONCLUSIONS: Arsenic trioxide is effective in the treatment of acute promyelocytic leukemia, but it can lead to an increase in triglyceride levels. Blood lipid regulation and cardioprotective drugs should be given attention.