经皮硝酸甘油释放系统(TNS)于1979年应用于临床,作者在1980年获得满意结果。本文通过双盲多交叉研究以估价TNS的临床有效性,并应用亚组分析以估价高剂量治疗是否更为有效。方法:56例中男39,女17例,平均年龄64(47～85)岁,均为劳力型心绞痛,舌下给予硝酸甘油片 Transcutaneous nitroglycerin delivery system (TNS) was applied to clinical in 1979, the author obtained satisfactory results in 1980. In this paper, a double-blind, multi-crossover study was conducted to evaluate the clinical effectiveness of TNS and to use subgroup analyzes to evaluate whether high-dose therapy is more effective. Methods: 56 males and 39 females, 17 cases, mean age 64 (47 ~ 85) years old, were labor-type angina, sublingual nitroglycerin tablets