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背景:降钙素具有提高骨量、骨质量,降低骨折发生的效果。目的:评价鲑鱼降钙素对羟基磷灰石植入体骨整合的影响,及其在治疗骨质疏松症同时促进植入体生物学固定的能力。方法:将SD大鼠随机分为假手术+羟基磷灰石棒组、卵巢切除+羟基磷灰石棒组、卵巢切除+降钙素+羟基磷灰石棒组,后2组建立绝经后骨质疏松动物模型。建模后分别在3组大鼠的胫骨平台处开孔植入多孔羟基磷灰石假体,卵巢切除+降钙素+羟基磷灰石棒组大鼠皮下注射鲑鱼降钙素12周。结果与结论:卵巢切除后,大鼠的腰椎骨密度降低,而持续皮下注射鲑鱼降钙素后,大鼠的腰椎骨密度逐渐改善。应用降钙素处理后的大鼠,其骨结合率较卵巢切除+羟基磷灰石棒组提高了22.0%(P<0.05)。结果证实,全身给予鲑鱼降钙素能提高骨质疏松大鼠骨床和植入体周围骨量、促进主体骨-植入体的骨整合。
Background: Calcitonin has the effect of increasing bone mass, bone mass and reducing fracture. OBJECTIVE: To evaluate the effect of salmon calcitonin on osseointegration of hydroxyapatite implants and its ability to treat osteoporosis while promoting implant bioprosthesis. Methods: SD rats were randomly divided into sham operation + hydroxyapatite rod group, ovariectomy + hydroxyapatite rod group, ovariectomy + calcitonin + hydroxyapatite rod group, the latter two groups were established postmenopausal bone Loose animal model. After modeling, porous hydroxyapatite implants were implanted into the tibial plateau of the three groups of rats respectively. Rats in ovariectomized + calcitonin + hydroxyapatite group were subcutaneously injected with salmon calcitonin for 12 weeks. RESULTS AND CONCLUSION: After ovariectomy, the lumbar spine BMD decreased in rats. After continuous subcutaneous injection of salmon calcitonin, BMD of lumbar vertebrae in rats gradually improved. Compared with ovariectomized + hydroxyapatite rod group, the osteocalcin content in calcitonin-treated rats increased by 22.0% (P <0.05). The results confirmed that systemic administration of salmon calcitonin can increase osteoporosis rat bone mass and bone around the implant, and promote the main bone - implant osteointegration.