利用手性双唑啉与三氟甲磺酸亚铜催化 2 -甲氧基苯乙烯与重氮乙酸二环己基甲酯的不对称环丙烷化反应合成了手性环丙烷羧酸酯 ,用氢氧化钠对其进行选择性水解得到全反式环丙烷羧酸 ,其 ee值经 GC测定为 88% .进一步经过 Curtius重排、烷基化等反应及重结晶等步骤合成了光学纯的具有生理活性的环丙胺化合物 1a和 1b. The chiral cyclopropanecarboxylates were synthesized by asymmetric cyclopropanation of 2 - methoxystyrene with dicyclohexylmethyl diazoacetate catalyzed by chiral bis (oxazoline) and cuprous triflate. The Selective hydrolysis of sodium hydroxide to give all-trans cyclopropanecarboxylic acid, the ee value determined by GC 88% .Through further Curtius rearrangement, alkylation reaction and recrystallization steps such as the synthesis of optically pure with Physiologically active cyclopropanamine compounds 1a and 1b.