论文部分内容阅读
为探讨预防型抗氟剂 (Ⅰ型 - 1) [PAA (Ⅰ - 1) ]的慢性毒性 ,选用 6 4只健康Wistar大鼠 ,随机分成 4组 ,即A组 (4 0 0mg/kg d) ,B组 (80mg/kg d) ,C组 (16mg/kg d)和D组 (对照组 )。灌胃给药 ,进行了为期 6个月的实验研究。结果表明 ,除高剂量组动物体重增长缓慢 ,尿常规、白细胞和血小板计数较低 (但与对照组比较差异无显著性 ) ,血清总蛋白、白蛋白、总胆固醇、甘油三酯 ,血清丙氨酸转氨酶、碱性磷酸酶、淀粉酶、尿素氮无显著变化 ,血清超氧化物歧化酶活性和微量元素高于对照组 ,但差异也无显著性。提示 ,[PAA (Ⅰ - 1) ]无明显的慢性毒作用
To investigate the chronic toxicity of prophylactic antifluoride (Ⅰ - 1) [PAA (Ⅰ - 1)], 64 healthy Wistar rats were randomly divided into 4 groups (A group, 400 mg / kg d) , Group B (80mg / kg d), group C (16mg / kg d) and group D (control group). Gavage administration, conducted a 6-month experimental study. The results showed that in addition to the slow increase of body weight in high dose group, urine routine, leukocyte and platelet count were lower (but no significant difference compared with the control group), serum total protein, albumin, total cholesterol, triglyceride, Acid aminotransferase, alkaline phosphatase, amylase, urea nitrogen no significant changes in serum superoxide dismutase activity and trace elements higher than the control group, but the difference was not significant. Tip, [PAA (Ⅰ - 1)] no significant chronic toxicity