目的探讨侵入颅内颅底骨化纤维瘤的临床特点。方法回顾性分析了手术切除并经病理证实的侵入颅内颅底骨化纤维瘤１５例患者的临床资料。结果本组病例男１１例，女４例，平均年龄２３５岁，肿瘤位于前中颅底１３例，影像学检查可辅助诊断，本组无手术死亡。结论手术切除是唯一的治疗方法，长期随访无严重并发症，因而主张应用颅底外科手术积极治疗是很有必要的 Objective To investigate the clinical features of invasive intracranial basal ossification fibroma. Methods The clinical data of 15 patients with intracranial craniocerebral ossification fibroma underwent surgical resection and confirmed by pathology were analyzed retrospectively. Results In this group, there were 11 males and 4 females, with an average age of 23 to 5 years. Tumors were located at the anterior and middle skull base in 13 cases. Imaging examinations can assist diagnosis. There was no operative death in this group. Conclusion Surgical resection is the only treatment method. There is no serious complication in long-term follow-up. Therefore, it is necessary to advocate active treatment with skull base surgery.