目的：探讨 Ｉ Ｌ６、 Ｉ Ｌ８ 与角膜移植的关系。方法：采集 １９ 例角膜移植患者术前 １ ｄ 及术后３～５ ｄ空腹静脉血，应用 Ｅ Ｌ Ｉ Ｓ Ａ 法测定血清中 ｓ Ｉ Ｌ６、ｓ Ｉ Ｌ８ 水平，应用流式细胞仪测定 Ｔ 淋巴细胞亚群的变化。结果：患者术前ｓ Ｉ Ｌ６、ｓ Ｉ Ｌ８ 水平接近正常人，术后明显升高，而 Ｔ 淋巴细胞亚群的改变则无统计学意义。结论： Ｉ Ｌ６、 Ｉ Ｌ８ 作为细胞因子较早参与了角膜移植术后的免疫反应。 Objective: To investigate the relationship between I L6 and I L8 and corneal transplantation. Methods: A total of 19 cases of corneal transplant patients were preoperative 1 d and 3 to 5 d after fasting venous blood, the application of E L I S A method of serum s I L 6, s I L 8 levels, the application of flow cytometry Measuring T lymphocyte subsets changes. Results: The levels of s I L6 and s IL8 in preoperative patients were close to those in normal people, and were significantly increased after operation. However, the changes of T lymphocyte subsets were not statistically significant. Conclusion: I L6, I L8 as a cytokine earlier involved in the immune response after corneal transplantation.